I've been playing TOME for about six months now, after a brief career in Zangband. Mostly I play on a heavily modified version of 2.3.4 (I can't help but tinker, that's what I love best about open source games), but I find that as I play I'm reverting more and more of my changes, so I imagine when TOME 3 is more stable, I'll play it "stock."
ToME Wiki